Practitioner's Guide to Designer Drugs

A. AH-7921 (3,4-dichloro-N-[(1-dimethylamino)- cyclohexylmethyl]benzamide) - Active at 20mg. Found in smoke blends in Japan in July 2013. As of December 2015, there do not appear to be any drug screens that will detect this compound or it’s metabolites.

B. MT-45 (1-cyclohexyl-4-(1,2-diphenylethyl)piperazine) - Active at 20mg. Seeing more people seeking out and asking questions about this compound on drug forums

C. Bromadol - 504x the potency of morphine for the trans-isomer. Found in fake oxycodone tablets in Canada in 2013.

D. Fentanyl derivatives
1. Acetylfentanyl - 40x the potency of heroin, this analogue has
popped up recently and killed at least 50 people, perhaps as a cheap substitute for heroin. Likely used to cut heroin prior to being sold on the street.

2. Butyrfentanyl - about a quarter of the potency of fentanyl.

3. 3-methylfentanyl (Kolokol-1) - between 400-6000x the potency of morphine. It has been used as a cut in “China White” heroin. Also suspected to have been used as an aerosol gas form in “Kolokol-1” in the 2002 Moscow Theater hostage crisis to sedate the militants, all 40 militants and over 100 hostages were killed directly from the gas.

4. Ohmefentanyl (N-[(3R,4S)-1-[(2S)-2-hydroxy-2-phenyl-ethyl] -3- methyl-4-piperidyl]-N-phenyl-propanamide) - 6300x the potency of morphine.

5. alpha-methylfentanyl - another chemical used as a cut in “China White” heroin.

6. desmethylfentanyl - found in fake oxycodone tablets in Canada in 2013.Continues to be found in counterfeit pain medication as of February 2014.

E. O-Desmethyltramadol - active at 20mg intranasal. An analogue of Tramadol, it is actually an active metabolite of Tramadol in the body. It has much greater affinity for μ-opioid receptors than Tramadol itself and is 17x the potency of morphine by weight. Used in an adulterated Kratom leaf blend called “Krypton” and caused several deaths consumed in this form. Considered to be recreationally desirable.

G. W-15 (1-Phenylethylpiperidylidene-2-(4-chlorophenyl)sulfonamide) - approximately 5.4x the potency of morphine in a phenylquinone writhing test.

F. W-18 (1-(4-Nitrophenylethyl)piperidylidene-2-(4- chlorophenyl)sulfonamide) - 10000x the potency of morphine in a phenylquinone writhing test, it is similar strength to carfentanyl but not structurally related to currently-scheduled opioids.

G. MPPP (1-Methyl-4-phenyl-4-propionoxypiperidine) - one that will hopefully never return. 70% the potency of morphine, MPPP has a common contaminant from sloppy synthesis called MPTP (1-Methyl-4- phenyl-1,2,3,6-tetrahydropyridine). MPTP is a potent dopaminergic neurotoxin and was responsible for several deaths and onsets of Parkinson’s disease.